Publisher Correction: Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks
نویسندگان
چکیده
A Correction to this paper has been published: https://doi.org/10.1038/s41556-021-00651-8.
منابع مشابه
Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility.
Twinfilins are conserved actin-binding proteins composed of two actin depolymerizing factor homology (ADF-H) domains. Twinfilins are involved in diverse morphological and motile processes, but their mechanism of action has not been elucidated. Here, we show that mammalian twinfilin both sequesters ADP-G-actin and caps filament barbed ends with preferential affinity for ADP-bound ends. Twinfilin...
متن کاملRegulators of actin filament barbed ends at a glance.
Cells respond to external stimuli by rapidly remodeling their actin cytoskeleton. At the heart of this function lies the intricately controlled regulation of individual filaments. The barbed end of an actin filament is the hotspot for the majority of the biochemical reactions that control filament assembly. Assays performed in bulk solution and with single filaments have enabled characterizatio...
متن کاملEna/VASP proteins capture actin filament barbed ends.
Ena/VASP (vasodialator-stimulated protein) proteins regulate many actin-dependent events, including formation of protrusive structures, fibroblast migration, neurite extension, cell-cell adhesion, and Listeria pathogenesis. In vitro, Ena/VASP activities on actin are complex and varied. They promote actin assembly, protect filaments from cappers, bundle filaments, and inhibit filament branching....
متن کاملLamellipodial Versus Filopodial Mode of the Actin Nanomachinery Pivotal Role of the Filament Barbed End
Understanding how a particular cell type expresses the lamellipodial or filopodial form of the actin machinery is essential to understanding a cell's functional interactions. To determine how a cell "chooses" among these alternative modes of "molecular hardware," we tested the role of key proteins that affect actin filament barbed ends. Depletion of capping protein (CP) by short hairpin RNA (sh...
متن کاملTwinfilin is an actin-filament-severing protein and promotes rapid turnover of actin structures in vivo.
Working in concert, multiple actin-binding proteins regulate the dynamic turnover of actin networks. Here, we define a novel function for the conserved actin-binding protein twinfilin, which until now was thought to function primarily as a monomer-sequestering protein. We show that purified budding yeast twinfilin (Twf1) binds to and severs actin filaments in vitro at pH below 6.0 in bulk kinet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2021
ISSN: ['1476-4679', '1465-7392']
DOI: https://doi.org/10.1038/s41556-021-00651-8